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Crystal structure of COLE7 translocation domain

Analyse Crystal structure of COLE7 translocation domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AXC
Type: protein
Length: 232 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Colicin E7
EC: 3.1.-.-
UniProt: Q47112
Ligands: SO4
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Colicin E7 (EC 3.1.-.-)	protein	232	19% helix, 38% strand	Q47112

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.39	0.78	19	empty
2	66	0.30	0.74	17	SO4

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

2AXC · Crystal structure of ColE7 translocation domain · the same entry in another collection · chain A against A, TM-score 1.00
Q47112 · AlphaFold monomer V2.0 prediction for colicin-E7 (Q47112) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q47112
Elsewhere: RCSB PDB 2AXC · PDBe 2AXC · UniProt Q47112

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