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CHYMOTRYPSINOGEN,2.5 ångströms crystal structure, comparison with alpha-CHYMOTRYPSIN,AND implications for zymogen activation

Analyse CHYMOTRYPSINOGEN,2.5 ångströms crystal structure, comparison with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CHG
Type: protein
Length: 226 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chymotrypsinogen a
UniProt: P00766
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chymotrypsinogen a	protein	226	9% helix, 37% strand	P00766

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.42	0.80	18	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

1CHG · CHYMOTRYPSINOGEN,2.5 ångströms crystal structure, comparison with alpha-CHYMOTRYPSIN,AND… · the same entry in another collection · chain A against A, TM-score 1.00
P00766 · AlphaFold monomer V2.0 prediction for chymotrypsinogen a (P00766) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00766
Elsewhere: RCSB PDB 1CHG · PDBe 1CHG · UniProt P00766

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