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Crystal structures of the mthk rck domain in no CA2+ bound form

Analyse Crystal structures of the mthk rck domain in no CA2+ bound form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AEJ
Type: protein
Length: 444 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-gated potassium channel mthk
UniProt: O27564
Pockets: 8 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calcium-gated potassium channel mthk	protein	224	39% helix, 22% strand	O27564
B	Calcium-gated potassium channel mthk	protein	220	39% helix, 23% strand	O27564

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	417	0.68	0.80	32	empty
2	191	0.45	0.74	20	empty
3	176	0.43	0.74	24	empty
4	130	0.43	0.76	18	empty
5	132	0.40	0.74	21	empty

Interfaces

1 interface between chains.

A–B · 3379 Å² buried · 45 hydrogen bonds · protein-protein

Compared structures

2AEJ · Crystal Structures of the MthK RCK Domain in no Ca2+ bound form · the same entry in another collection · chain A against A, TM-score 1.00
O27564 · AlphaFold monomer V2.0 prediction for calcium-gated potassium channel mthk (O27564) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O27564
Elsewhere: RCSB PDB 2AEJ · PDBe 2AEJ · UniProt O27564

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