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Discovery, structural determination and processing of the precursor protein that produces the cyclic trypsin inhibitor sfti-1

Analyse Discovery, structural determination and processing of the precursor protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AB9
Type: protein
Length: 31 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pro-sfti-1
UniProt: Q4GWU5
Pockets: 1 · best druggability 0.25

Structure

solution nmr · 1 distinct chain · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pro-sfti-1	protein	31	0% helix, 0% strand	Q4GWU5

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.25	0.73	15	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2AB9 · Discovery, structural determination and processing of the precursor protein that produces… · the same entry in another collection · chain A against A, TM-score 1.00
Q4GWU5 · AlphaFold monomer V2.0 prediction for trypsin inhibitor 1 (Q4GWU5) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4GWU5
Elsewhere: RCSB PDB 2AB9 · PDBe 2AB9 · UniProt Q4GWU5

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