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Mineralocorticoid receptor with bound deoxycorticosterone

Analyse Mineralocorticoid receptor with bound deoxycorticosterone in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AA7
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mineralocorticoid receptor
UniProt: P08235
Ligands: 1CA, SO4
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mineralocorticoid receptor	protein	253	68% helix, 5% strand	P08235

Ligands and binding sites

1CA · Desoxycorticosterone · ligand · chains A
SO4 · Sulfate ion · ion · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.83	0.98	23	1CA
2	131	0.68	0.89	20	SO4, GOL
3	96	0.48	0.81	22	empty

Compared structures

2AA7 · Mineralocorticoid Receptor with Bound Deoxycorticosterone · the same entry in another collection · chain A against A, TM-score 1.00
P08235 · AlphaFold monomer V2.0 prediction for mineralocorticoid receptor (P08235) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08235
Elsewhere: RCSB PDB 2AA7 · PDBe 2AA7 · UniProt P08235

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