UniProt P08235
Mineralocorticoid receptor (P08235)
Mineralocorticoid receptor (UniProt P08235): 58 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08235
- Protein
- Mineralocorticoid receptor
- Experimental structures
- 58
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 49 · 10 records with a druggable one
Structures
59 records of P08235 in the MolNFT archive: 58 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y9R | Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to… | x-ray diffraction | A, B | 1CA | 8 (best 0.83) |
| 1Y9R | Crystal structure of the human mineralocorticoid receptor ligand- binding domain bound to… | x-ray diffraction | A, B | — | — |
| 1YA3 | Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to… | x-ray diffraction | A, B, C | STR | 10 (best 0.84) |
| 1YA3 | Crystal structure of the human mineralocorticoid receptor ligand- binding domain bound to… | x-ray diffraction | A, B, C | — | — |
| 2A3I | Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and Coactivator… | x-ray diffraction | A | — | — |
| 2A3I | Structural and biochemical mechanisms for the specificity of hormone binding and coactivator… | x-ray diffraction | A | — | — |
| 2AA2 | Mineralocorticoid Receptor with Bound Aldosterone | x-ray diffraction | A | — | — |
| 2AA2 | Mineralocorticoid receptor with bound aldosterone | x-ray diffraction | A | — | — |
| 2AA5 | Mineralocorticoid Receptor with Bound Progesterone | x-ray diffraction | A, B | — | — |
| 2AA5 | Mineralocorticoid receptor with bound progesterone | x-ray diffraction | A, B | — | — |
| 2AA6 | Mineralocorticoid Receptor S810L Mutant with Bound Progesterone | x-ray diffraction | A, B | — | — |
| 2AA6 | Mineralocorticoid receptor S810L mutant with bound progesterone | x-ray diffraction | A, B | — | — |
| 2AA7 | Mineralocorticoid Receptor with Bound Deoxycorticosterone | x-ray diffraction | A | — | — |
| 2AA7 | Mineralocorticoid receptor with bound deoxycorticosterone | x-ray diffraction | A | — | — |
| 2AAX | Mineralocorticoid Receptor Double Mutant with Bound Cortisone | x-ray diffraction | A, B | — | — |
| 2AAX | Mineralocorticoid receptor double mutant with bound cortisone | x-ray diffraction | A, B | — | — |
| 2AB2 | Mineralocorticoid Receptor Double Mutant with Bound Spironolactone | x-ray diffraction | A, B | — | — |
| 2AB2 | Mineralocorticoid receptor double mutant with bound spironolactone | x-ray diffraction | A, B | — | — |
| 2ABI | Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to… | x-ray diffraction | A, B, C | — | — |
| 2ABI | Crystal structure of the human mineralocorticoid receptor ligand- binding domain bound to… | x-ray diffraction | A, B, C | — | — |
| 2OAX | Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2OAX | Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3VHU | Mineralocorticoid receptor ligand-binding domain with spironolactone | x-ray diffraction | A | — | — |
| 3VHU | Mineralocorticoid receptor ligand-binding domain with spironolactone | x-ray diffraction | A | — | — |
| 3VHV | Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist | x-ray diffraction | A | — | — |
| 3VHV | Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist | x-ray diffraction | A | — | — |
| 3WFF | Mineralocorticoid receptor ligand-binding domain with compound 2b | x-ray diffraction | A | — | — |
| 3WFF | Mineralocorticoid receptor ligand-binding domain with compound 2B | x-ray diffraction | A | — | — |
| 3WFG | Mineralocorticoid receptor ligand-binding domain with compuond 2e | x-ray diffraction | A | — | — |
| 3WFG | Mineralocorticoid receptor ligand-binding domain with compuond 2E | x-ray diffraction | A | — | — |
| 4PF3 | Mineralocorticoid receptor ligand-binding domain with compuond 37a | x-ray diffraction | A | — | — |
| 4PF3 | Mineralocorticoid receptor ligand-binding domain with compuond 37A | x-ray diffraction | A | — | — |
| 4TNT | Structure of the human mineralocorticoid receptor in complex with DNA | x-ray diffraction | A, B | — | — |
| 4TNT | Structure of the human mineralocorticoid receptor in complex with DNA | x-ray diffraction | A, B | — | — |
| 4UDA | MR in complex with dexamethasone | x-ray diffraction | A | — | — |
| 4UDA | Mr in complex with dexamethasone | x-ray diffraction | A | — | — |
| 4UDB | MR in complex with desisobutyrylciclesonide | x-ray diffraction | A | — | — |
| 4UDB | Mr in complex with desisobutyrylciclesonide | x-ray diffraction | A | — | — |
| 5HCV | Identification of Spirooxindole and Dibenzoxazepine Motifs as Potent Mineralocorticoid Receptor… | x-ray diffraction | A, B, C | 60R, CL | — |
| 5HCV | Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor… | x-ray diffraction | A, B, C | — | — |
| 5L7E | MCR IN COMPLEX WITH ligand | x-ray diffraction | A | SO4, 6Q0 | 3 (best 0.83) |
| 5L7E | Mcr in complex with ligand | x-ray diffraction | A | SO4, 6Q0 | — |
| 5L7G | MCR IN COMPLEX WITH ligand | x-ray diffraction | A | 6QE | 3 (best 0.84) |
| 5L7G | Mcr in complex with ligand | x-ray diffraction | A | 6QE | — |
| 5L7H | MCR IN COMPLEX WITH ligand | x-ray diffraction | A | 6QG | — |
| 5L7H | Mcr in complex with ligand | x-ray diffraction | A | 6QG | — |
| 5MWP | The structure of MR in complex with AZD9977. | x-ray diffraction | A | ECV | 3 (best 0.84) |
| 5MWP | The structure of mr in complex with AZD9977. | x-ray diffraction | A | ECV | — |
| 5MWY | The structure of MR in complex with eplere . | x-ray diffraction | A | YNU | — |
| 5MWY | The structure of mr in complex with eplerenone. | x-ray diffraction | A | YNU | — |
| 6GEV | Mineralocorticoid receptor in complex with (s)-13 | x-ray diffraction | A | EWN | 3 (best 0.85) |
| 6GEV | Mineralocorticoid receptor in complex with (S)-13 | x-ray diffraction | A | EWN | — |
| 6GG8 | Mineralocorticoid receptor in complex with (s)-13 | x-ray diffraction | A | EY8 | 3 (best 0.83) |
| 6GG8 | Mineralocorticoid receptor in complex with (S)-13 | x-ray diffraction | A | EY8 | — |
| 6GGG | Mineralocorticoid receptor in complex with (s)-13 | x-ray diffraction | A | CL, EYN | 3 (best 0.85) |
| 6GGG | Mineralocorticoid receptor in complex with (S)-13 | x-ray diffraction | A | CL, EYN | — |
| 6L88 | Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxere | x-ray diffraction | A, B, C, D | E6R | 6 (best 0.77) |
| 6L88 | Crystal structure of mineralocorticoid receptor ligand binding domain in complex with esaxerenone | x-ray diffraction | A, B, C, D | E6R | — |
| P08235 | AlphaFold monomer V2.0 prediction for mineralocorticoid receptor (P08235) | predicted | A | — | 7 (best 0.82) |
Ligands
- CL · Chloride ion · in 3 records
- 6Q0 · ~{N}-[[4-(3,5-dimethyl-1,2-oxazol-4-yl) phenyl]methyl]benzenesulfonamide · in 2 records
- 6QE · ~{N}-[[4-[5-[[2,3-bis(fluoranyl)phenoxy]methyl]-3-methyl-1,2-oxazol-4-yl]phenyl]methyl]-1-methyl-cyclopropane-1-sulfonamide · in 2 records
- 6QG · 3-methyl-5,8-dioxa-17lambda-thia-4,18-diazatetracyclo[18.2.2.1,.0]pentacosa-1(22),2(6),3,9, 11,13(25),20,23-octaene-17,17-dione · in 2 records
- E6R · 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide · in 2 records
- ECV · 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide · in 2 records
- EWN · 6-[[(3~{S})-7-fluoranyl-3-(2-methylpropyl)-2,3-dihydro-1,4-benzoxazin-4-yl]carbonyl]-4~{H}-1,4-benzoxazin-3-one · in 2 records
- EY8 · [(3~{R})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]methanesulfonamide · in 2 records
- EYN · 2-[(3~{S})-7-fluoranyl-6-(2-methylpropyl)-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- YNU · eplerenone · in 2 records
- 1CA · Desoxycorticosterone · in 1 record
- 60R · 6-[(~{E})-(3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene)methyl]-4~{H}-1,4-benzoxazin-3-one · in 1 record
- STR · Progesterone · in 1 record
Experiment against prediction
- 5L7E chain A against the predicted model P08235: TM-score 0.99, RMSD 0.52 Å
- 5L7E chain A against the predicted model P08235: TM-score 0.99, RMSD 0.52 Å
- 6GG8 chain A against the predicted model P08235: TM-score 0.99, RMSD 0.54 Å
- 6GG8 chain A against the predicted model P08235: TM-score 0.99, RMSD 0.54 Å
- 5HCV chain C against the predicted model P08235: TM-score 0.99, RMSD 0.52 Å
- 5HCV chain C against the predicted model P08235: TM-score 0.99, RMSD 0.52 Å
- 1YA3 chain B against the predicted model P08235: TM-score 0.99, RMSD 0.59 Å
- 1YA3 chain B against the predicted model P08235: TM-score 0.99, RMSD 0.59 Å
- 2OAX chain D against the predicted model P08235: TM-score 0.99, RMSD 0.61 Å
- 2OAX chain D against the predicted model P08235: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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