Research workbench
Structure of the N-terminal domain of human ubiquitin carboxyl-terminal hydrolase 8 (USP8)
Analyse Structure of the N-terminal domain of human ubiquitin carboxyl-terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A9U
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 8
- EC
- 3.1.2.15
- UniProt
- P40818
- Pockets
- 1 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) | protein | 134 | 81% helix, 0% strand | P40818 |
| B | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) | protein | 127 | 77% helix, 0% strand | P40818 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 781 | 0.73 | 0.78 | 42 | empty |
Interfaces
1 interface between chains.
- A–B · 1901 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 2A9U · Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8) · the same entry in another collection · chain A against A, TM-score 1.00
- P40818 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 8 (P40818) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40818
- Elsewhere: RCSB PDB 2A9U · PDBe 2A9U · UniProt P40818
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