Research workbench
Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh.
Analyse Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A94
- Type
- protein
- Length
- 315 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate dehydrogenase
- EC
- 1.1.1.27
- UniProt
- Q27743
- Ligands
- AP0
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 315 | 47% helix, 20% strand | Q27743 |
Ligands and binding sites
- AP0 · Acetyl pyridine adenine dinucleotide, reduced · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.74 | 0.84 | 59 | AP0 |
| 2 | 51 | 0.46 | 0.86 | 18 | empty |
| 3 | 126 | 0.43 | 0.76 | 26 | empty |
| 4 | 63 | 0.28 | 0.73 | 16 | empty |
Compared structures
- 2A94 · Structure of Plasmodium falciparum lactate dehydrogenase complexed to APADH. · the same entry in another collection · chain A against A, TM-score 1.00
- Q27743 · AlphaFold monomer V2.0 prediction for L-lactate dehydrogenase (Q27743) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q27743
- Elsewhere: RCSB PDB 2A94 · PDBe 2A94 · UniProt Q27743
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