UniProt Q27743
L-lactate dehydrogenase (Q27743)
L-lactate dehydrogenase (UniProt Q27743), EC 1.1.1.27: 32 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q27743
- Protein
- L-lactate dehydrogenase
- EC
- 1.1.1.27
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 54 · 16 records with a druggable one
Structures
33 records of Q27743 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CEQ | Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase. | x-ray diffraction | A | — | 3 (best 0.66) |
| 1CEQ | Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase. | x-ray diffraction | A | — | — |
| 1CET | Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase. | x-ray diffraction | A | CLQ | 3 (best 0.69) |
| 1CET | Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase. | x-ray diffraction | A | — | — |
| 1LDG | Plasmodium falciparum L-lactate dehydrogenase complexed with NADH and oxamate | x-ray diffraction | A | NAI, OXM | 4 (best 0.68) |
| 1LDG | Plasmodium falciparum L-lactate dehydrogenase complexed with NADH and oxamate | x-ray diffraction | A | — | — |
| 1T24 | Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and… | x-ray diffraction | A | NAD, OXQ | 3 (best 0.69) |
| 1T24 | Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4… | x-ray diffraction | A | — | — |
| 1T25 | Plasmodium falciparum lactate dehydrogenase complexed with NADH and 3-hydroxyisoxazole-4-carboxylic… | x-ray diffraction | A | NAI, GAG | 5 (best 0.70) |
| 1T25 | Plasmodium falciparum lactate dehydrogenase complexed with NADH and 3… | x-ray diffraction | A | — | — |
| 1T26 | Plasmodium falciparum lactate dehydrogenase complexed with NADH and… | x-ray diffraction | A | NAI, GBD | 3 (best 0.70) |
| 1T26 | Plasmodium falciparum lactate dehydrogenase complexed with NADH and 4… | x-ray diffraction | A | — | — |
| 1T2C | Plasmodium falciparum lactate dehydrogenase complexed with NADH | x-ray diffraction | A | NAI | 4 (best 0.74) |
| 1T2C | Plasmodium falciparum lactate dehydrogenase complexed with NADH | x-ray diffraction | A | — | — |
| 1T2D | Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate | x-ray diffraction | A | OXL, NAD | 3 (best 0.67) |
| 1T2D | Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate | x-ray diffraction | A | — | — |
| 1T2E | Plasmodium falciparum lactate dehydrogenase S245A, A327P mutant complexed with NADH and oxamate | x-ray diffraction | A | NAI, OXM | 3 (best 0.69) |
| 1T2E | Plasmodium falciparum lactate dehydrogenase S245A, A327P mutant complexed with NADH and oxamate | x-ray diffraction | A | — | — |
| 1U4O | Plasmodium falciparum lactate dehydrogenase complexed with 2,6-naphthalenedicarboxylic acid | x-ray diffraction | A | NDD | 3 (best 0.69) |
| 1U4O | Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedicarboxylic acid | x-ray diffraction | A | — | — |
| 1U4S | Plasmodium falciparum lactate dehydrogenase complexed with 2,6-naphthalenedisulphonic acid | x-ray diffraction | A | BIH | 3 (best 0.67) |
| 1U4S | Plasmodium falciparum lactate dehydrogenase complexed with 2,6- naphthalenedisulphonic acid | x-ray diffraction | A | — | — |
| 1U5A | Plasmodium falciparum lactate dehydrogenase complexed with 3,5-dihydroxy-2-naphthoic acid | x-ray diffraction | A | BIK | 3 (best 0.65) |
| 1U5A | Plasmodium falciparum lactate dehydrogenase complexed with 3,5- dihydroxy-2-naphthoic acid | x-ray diffraction | A | — | — |
| 1U5C | Plasmodium falciparum lactate dehydrogenase complexed with 3,7-dihydroxynaphthalene-2-carboxylic… | x-ray diffraction | A | NAD, BIK | 3 (best 0.66) |
| 1U5C | Plasmodium falciparum lactate dehydrogenase complexed with 3,7- dihydroxynaphthalene-2-carboxylic… | x-ray diffraction | A | — | — |
| 1XIV | Plasmodium falciparum lactate dehydrogenase complexed with… | x-ray diffraction | A | RB2 | 3 (best 0.63) |
| 1XIV | Plasmodium falciparum lactate dehydrogenase complexed with 2-({4… | x-ray diffraction | A | — | — |
| 2A94 | Structure of Plasmodium falciparum lactate dehydrogenase complexed to APADH. | x-ray diffraction | A | AP0 | 4 (best 0.74) |
| 2A94 | Structure of plasmodium falciparum lactate dehydrogenase complexed to apadh. | x-ray diffraction | A | — | — |
| 2X8L | Plasmodium falciparum lactate dehydrogenase apo structure | x-ray diffraction | A | — | — |
| 2X8L | Plasmodium falciparum lactate dehydrogenase apo structure | x-ray diffraction | A | — | — |
| Q27743 | AlphaFold monomer V2.0 prediction for L-lactate dehydrogenase (Q27743) | predicted | A | — | 4 (best 0.67) |
Ligands
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 5 records
- NAD · Nicotinamide-adenine-dinucleotide · in 3 records
- BIK · 3,7-dihydroxy-2-naphthoic acid · in 2 records
- OXM · Oxamic acid · in 2 records
- AP0 · Acetyl pyridine adenine dinucleotide, reduced · in 1 record
- BIH · Naphthalene-2,6-disulfonic acid · in 1 record
- CLQ · N4-(7-chloro-quinolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine · in 1 record
- GAG · 3-hydroxyisoxazole-4-carboxylic acid · in 1 record
- GBD · 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid · in 1 record
- NDD · 2,6-dicarboxynaphthalene · in 1 record
- OXL · Oxalate ion · in 1 record
- OXQ · 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid · in 1 record
- RB2 · 2-({4-chloro-2-[hydroxy(methoxy)methyl]cyclohexyl}amino)ethane-1,1,2-triol · in 1 record
Experiment against prediction
- 1LDG chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.48 Å
- 1LDG chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.48 Å
- 1T24 chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.50 Å
- 1T24 chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.50 Å
- 1T2D chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.50 Å
- 1T2D chain A against the predicted model Q27743: TM-score 1.00, RMSD 0.50 Å
- 1T25 chain A against the predicted model Q27743: TM-score 0.99, RMSD 0.55 Å
- 1T25 chain A against the predicted model Q27743: TM-score 0.99, RMSD 0.55 Å
- 1T26 chain A against the predicted model Q27743: TM-score 0.99, RMSD 0.52 Å
- 1T26 chain A against the predicted model Q27743: TM-score 0.99, RMSD 0.52 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.