Research workbench
Mammalian shaker KV1.2 potassium channel- beta subunit complex
Analyse Mammalian shaker KV1.2 potassium channel- beta subunit complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A79
- Type
- protein
- Length
- 658 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel beta-2 subunit; Potassium voltage-gated channel subfamily…
- UniProt
- P62483, P63142
- Ligands
- NAP, K
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 60% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated potassium channel beta-2 subunit | protein | 326 | 51% helix, 16% strand | P62483 |
| B | Potassium voltage-gated channel subfamily a member 2 | protein | 259 | 64% helix, 7% strand | P63142 |
| C | Poly-unknown chain | protein | 52 | 81% helix, 0% strand | — |
| D | Poly-unknown chain | protein | 21 | 76% helix, 0% strand | — |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- K · Potassium ion · metal · 6 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.71 | 0.84 | 50 | NAP |
| 2 | 213 | 0.55 | 0.78 | 33 | empty |
| 3 | 190 | 0.52 | 0.77 | 28 | empty |
| 4 | 150 | 0.43 | 0.75 | 28 | empty |
| 5 | 54 | 0.36 | 0.79 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 399 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 386 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 324 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2A79 · Mammalian Shaker Kv1.2 potassium channel- beta subunit complex · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 1.00
- P63142 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Every structure of UniProt P63142
- Elsewhere: RCSB PDB 2A79 · PDBe 2A79 · UniProt P62483 · UniProt P63142
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