Research workbench
Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor
Analyse Structural and biochemical mechanisms for the specificity of hormone binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A3I
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mineralocorticoid receptor; Nuclear receptor coactivator 1, residues 1430-1441
- EC
- 2.3.1.48
- UniProt
- P08235, Q15788
- Ligands
- C0R
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mineralocorticoid receptor | protein | 253 | 68% helix, 5% strand | P08235 |
| B | Nuclear receptor coactivator 1, residues 1430-1441 (EC 2.3.1.48) | protein | 12 | 58% helix, 0% strand | Q15788 |
Ligands and binding sites
- C0R · Corticosterone · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.83 | 0.98 | 23 | C0R |
| 2 | 127 | 0.68 | 0.89 | 24 | empty |
| 3 | 97 | 0.47 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 538 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2A3I · Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and… · the same entry in another collection · chain A against A, TM-score 1.00
- P08235 · AlphaFold monomer V2.0 prediction for mineralocorticoid receptor (P08235) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08235
- Every structure of UniProt Q15788
- Elsewhere: RCSB PDB 2A3I · PDBe 2A3I · UniProt P08235 · UniProt Q15788
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.