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Crystal structure of the N-terminus of titin

Analyse Crystal structure of the N-terminus of titin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2A38
Type: protein
Length: 582 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Titin
EC: 2.7.11.1
UniProt: Q8WZ42
Ligands: CD
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 64% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Titin (EC 2.7.11.1)	protein	194	3% helix, 64% strand	Q8WZ42

Ligands and binding sites

CD · Cadmium ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	524	0.68	0.79	43	empty
2	217	0.53	0.77	31	empty
3	93	0.48	0.82	18	empty
4	114	0.38	0.74	21	empty
5	90	0.36	0.75	19	empty

Interfaces

2 interfaces between chains.

A–C · 820 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 324 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2A38 · Crystal structure of the N-Terminus of titin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WZ42
Elsewhere: RCSB PDB 2A38 · PDBe 2A38 · UniProt Q8WZ42

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