Research workbench
Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding sequence specificity
Analyse Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 277D
- Type
- DNA
- Length
- 6 nucleotides
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*CP*GP*CP*(G49)P*CP*G)-3'
- Ligands
- DM8
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5'-D(*CP*GP*CP*(G49)P*CP*G)-3' | dna | 6 | — | — |
Ligands and binding sites
- DM8 · 2'-bromo-4'-epidaunorubicin · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, nucleotide modification).
Compared structures
- 277D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 277D · PDBe 277D
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