GL1X · GenesisL1 explorer

Ligand · DM8

DM8 · 2'-bromo-4'-epidaunorubicin

DM8, 2'-bromo-4'-epidaunorubicin (C27 H28 Br N O10, 606.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
DM8
Formula
C27 H28 Br N O10
Class
ligand
Structures
12
PDB entries
6

Binding sites

DM8 in 12 structures; the first of them:

  • 276D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DC5, DG6
  • 277D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds G494, DC5, DG6
  • 278D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DC4, DC5, DG6
  • 288D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DA4, DC5, DG6
  • 380D · Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the… · DM8 A7 · binds DC1, DG2, G493, CBR4, CBR10, DC11, DG12
  • 381D · Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the… · DM8 A14 · binds DT1, DG2, DG3, DC4, DC10, DC11, DG12
  • 276D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DC5, DG6
  • 277D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds G494, DC5, DG6
  • 278D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DC4, DC5, DG6
  • 288D · Substitutions at C2' of daunosamine in the anticancer daunorubicin alter its DNA-binding… · DM8 A7 · binds DA4, DC5, DG6
  • 380D · Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the… · DM8 A7 · binds DC1, DG2, G493, CBR4, CBR10, DC11, DG12
  • 381D · Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the… · DM8 A14 · binds DT1, DG2, DG3, DC4, DC10, DC11, DG12

Residues it binds most

DC 16, DG 16, CBR 4, G49 8, DT 4, DA 2 (residue and the binding sites it lines).

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.