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Solution structure of a semi-synthetic C5A receptor antagonist at pH 5.2, 303K, NMR, 20 structures
Analyse Solution structure of a semi-synthetic C5A receptor antagonist at pH 5.2, 303K… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CFA
- Type
- protein
- Length
- 75 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement 5A semi-synthetic antagonist; Synthetic N-terminal tail
- UniProt
- P01031
Structure
solution nmr · 2 distinct chains · 52% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement 5A semi-synthetic antagonist | protein | 71 | 55% helix, 0% strand | P01031 |
| B | Synthetic N-terminal tail | protein | 4 | 0% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 280 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 d-amino (disulfide, D-amino acid).
Compared structures
- 1CFA · Solution structure of a semi-synthetic C5A receptor antagonist at pH 5.2, 303K, NMR, 20… · the same entry in another collection · chain A against A, TM-score 1.00
- P01031 · AlphaFold monomer V2.0 prediction for complement C5 (P01031) · a predicted model of the same protein · chain A against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01031
- Elsewhere: RCSB PDB 1CFA · PDBe 1CFA · UniProt P01031
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