UniProt P01031
Complement C5 (P01031)
Complement C5 (UniProt P01031): 59 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 114 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01031
- Protein
- Complement C5
- Experimental structures
- 59
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 114 · 10 records with a druggable one
Structures
60 records of P01031 in the MolNFT archive: 59 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CFA | Solution structure of a semi-synthetic C5A receptor antagonist at pH 5.2, 303K, NMR, 20 structures | solution nmr | A | — | — |
| 1CFA | Solution structure of a semi-synthetic C5A receptor antagonist at pH 5.2, 303K, NMR, 20 structures | solution nmr | A | — | — |
| 1KJS | NMR solution structure of C5A at pH 5.2, 303K, 20 structures | solution nmr | A | — | — |
| 1KJS | NMR solution structure of C5A at pH 5.2, 303K, 20 structures | solution nmr | A | — | — |
| 1XWE | NMR Structure of C345C (NTR) domain of C5 of complement | solution nmr | A | — | — |
| 1XWE | NMR structure of C345C (ntr) domain of C5 of complement | solution nmr | A | — | — |
| 3CU7 | Human Complement Component 5 | x-ray diffraction | A, B | — | — |
| 3CU7 | Human complement component 5 | x-ray diffraction | A, B | — | — |
| 3HQA | Crystal structure of human desarg-C5A | x-ray diffraction | A, B | — | — |
| 3HQA | Crystal structure of human desarg-C5A | x-ray diffraction | A, B | — | — |
| 3HQB | Crystal structure of human desarg-C5A | x-ray diffraction | A, B | — | — |
| 3HQB | Crystal structure of human desarg-C5A | x-ray diffraction | A, B | — | — |
| 3KLS | Structure of complement C5 in complex with SSL7 | x-ray diffraction | A, B | — | — |
| 3KLS | Structure of complement C5 in complex with SSL7 | x-ray diffraction | A, B | — | — |
| 3KM9 | Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 | x-ray diffraction | A, B | — | — |
| 3KM9 | Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 | x-ray diffraction | A, B | — | — |
| 3PRX | Structure of Complement C5 in Complex with CVF and SSL7 | x-ray diffraction | A, C | — | — |
| 3PRX | Structure of complement C5 in complex with cvf and SSL7 | x-ray diffraction | A, C | — | — |
| 3PVM | Structure of Complement C5 in Complex with CVF | x-ray diffraction | A, C | — | — |
| 3PVM | Structure of complement C5 in complex with cvf | x-ray diffraction | A, C | — | — |
| 4A5W | Crystal structure of C5b6 | x-ray diffraction | A | — | — |
| 4A5W | Crystal structure of C5B6 | x-ray diffraction | A | — | — |
| 4E0S | Crystal Structure of C5b-6 | x-ray diffraction | A | — | — |
| 4E0S | Crystal structure of C5B-6 | x-ray diffraction | A | — | — |
| 4P39 | Crystal structure of the human C5aR antagonist C5a-A8 | x-ray diffraction | A, B, C, D | — | — |
| 4P39 | Crystal structure of the human C5AR antagonist C5A-A8 | x-ray diffraction | A, B, C, D | — | — |
| 4UU9 | Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody | x-ray diffraction | C, D | — | — |
| 4UU9 | Crystal structure of the human C5A in complex with MEDI7814 a neutralising antibody | x-ray diffraction | C, D | — | — |
| 5B4P | Complex structure of human C5a and its binding repebody | x-ray diffraction | B, D | — | — |
| 5B4P | Complex structure of human C5A and its binding repebody | x-ray diffraction | B, D | — | — |
| 5B71 | Crystal structure of complement C5 in complex with SKY59 | x-ray diffraction | E, F | — | 3 (best 0.39) |
| 5B71 | Crystal structure of complement C5 in complex with SKY59 | x-ray diffraction | E, F | — | — |
| 5HCC | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni… | x-ray diffraction | B, A | NAG | — |
| 5HCC | Ternary complex of human complement C5 with ornithodoros moubata omci and dermacentor andersoni… | x-ray diffraction | B, A | — | — |
| 5HCD | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus… | x-ray diffraction | B, A | NAG | — |
| 5HCD | Ternary complex of human complement C5 with ornithodoros moubata omci and rhipicephalus microplus… | x-ray diffraction | B, A | — | — |
| 5HCE | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus… | x-ray diffraction | B, A | NAG, CYS | 19 (best 0.80) |
| 5HCE | Ternary complex of human complement C5 with ornithodoros moubata omci and rhipicephalus… | x-ray diffraction | B, A | — | — |
| 5I5K | Structure of complement C5 in complex with eculizumab | x-ray diffraction | B, A | NAG | — |
| 5I5K | Structure of complement C5 in complex with eculizumab | x-ray diffraction | B, A | — | — |
| 6H03 | Open conformation of the membrane attack complex | electron microscopy | A | — | — |
| 6H04 | Closed conformation of the Membrane Attack Complex | electron microscopy | A | — | — |
| 6H04 | Closed conformation of the membrane attack complex | electron microscopy | A | — | — |
| 6I2X | Structure of complement C5 in complex with small molecule inhibitor and cvf | electron crystallography | C, A | H1H | — |
| 6RPT | Structure of tick complement inhibitor CIRPT1 complexed with macroglobubulin domain 4 of human… | x-ray diffraction | E, A, C | — | — |
| 6RQJ | Structure of human complement C5 complexed with tick inhibitors omci, RACI1 and CIRPT1 | electron microscopy | A, B | NAG | — |
| 7AD6 | Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. | x-ray diffraction | A, B | NAG, CYS | 20 (best 0.80) |
| 7AD6 | Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. | x-ray diffraction | A, B | NAG | — |
| 7AD7 | Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. | x-ray diffraction | B, A | NAG, MHA, CYS | 20 (best 0.78) |
| 7AD7 | Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. | x-ray diffraction | B, A | NAG, MHA | — |
| 7NYC | Cryoem structure of 3C9-smac | electron microscopy | A | NAG | — |
| 7OP0 | Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. | x-ray diffraction | A, B | NAG | — |
| 7Y64 | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | electron microscopy | E | — | 2 (best 0.79) |
| 8AYH | Structure of Complement C5 in Complex with small molecule inhibitor and CVF | electron microscopy | C, A | H1H | 12 (best 0.86) |
| 8B0G | 2C9, C5b9-CD59 structure | electron microscopy | A | NAG | 6 (best 0.79) |
| 8B0H | 2C9, C5b9-CD59 cryoEM structure | electron microscopy | A | — | 8 (best 0.82) |
| 8COE | complement C5 in complex with the LCP0195 nanobody | x-ray diffraction | C, A | NAG | 20 (best 0.81) |
| 8HQC | Structure of a GPCR-G protein in complex with a natural peptide agonist | electron microscopy | D | — | 1 (best 0.78) |
| 8JZZ | Structure of human C5a-desArg bound human C5aR1 in complex with Go | electron microscopy | D | — | 3 (best 0.78) |
| P01031 | AlphaFold monomer V2.0 prediction for complement C5 (P01031) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7AD7 chain A against the predicted model P01031: TM-score 0.99, RMSD 1.06 Å
- 7AD7 chain A against the predicted model P01031: TM-score 0.99, RMSD 1.06 Å
- 3CU7 chain B against the predicted model P01031: TM-score 0.99, RMSD 1.50 Å
- 3CU7 chain B against the predicted model P01031: TM-score 0.99, RMSD 1.50 Å
- 3KLS chain B against the predicted model P01031: TM-score 0.99, RMSD 1.51 Å
- 3KLS chain B against the predicted model P01031: TM-score 0.99, RMSD 1.51 Å
- 3KM9 chain A against the predicted model P01031: TM-score 0.99, RMSD 1.52 Å
- 3KM9 chain A against the predicted model P01031: TM-score 0.99, RMSD 1.52 Å
- 3KM9 chain B against the predicted model P01031: TM-score 0.99, RMSD 1.52 Å
- 3KM9 chain B against the predicted model P01031: TM-score 0.99, RMSD 1.52 Å
Elsewhere
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