Crystal structure of the complex of a group iia phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 9% strand (DSSP).

Ligands and binding sites

• LCF · [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid · ligand · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

• 1ZYX · Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic… · the same entry in another collection · chain A against A, TM-score 1.00
• P59071 · AlphaFold monomer V2.0 prediction for basic phospholipase A2 vrv-pl- viiia (P59071) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P59071
• Elsewhere: RCSB PDB 1ZYX · PDBe 1ZYX · UniProt P59071