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Ligand · LCF

LCF · [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

LCF, [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid (C23 H22 Cl N O2, 379.9 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
LCF
Formula
C23 H22 Cl N O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

LCF in 4 structures; the first of them:

  • 1ZYX · Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic… · LCF A2001 · binds LEU2, PHE5, ALA18, ILE19, SER23, GLY30, TRP31
  • 4G8H · Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A… · LCF A711 · binds THR430, GLU431, GLY432, VAL591, ALA592, PRO593, GLU659, TYR660 and 1 more
  • 1ZYX · Crystal structure of the complex of a group iia phospholipase A2 with a synthetic… · LCF A2001 · binds LEU2, PHE5, ALA18, ILE19, SER23, GLY30, TRP31
  • 4G8H · Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 a… · LCF A711 · binds THR430, GLU431, GLY432, VAL591, ALA592, PRO593, GLU659, TYR660 and 1 more

Residues it binds most

GLY 4, ALA 4, GLU 2, ILE 2, LEU 2, PHE 2, PRO 2, SER 2, THR 2, TRP 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • FE · Fe (III) ion
  • ZN · Zinc ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CO3 · Carbonate ion

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