Research workbench
Crystal structure of EIF2ALPHA protein kinase GCN2: R794G hyperactivating mutant in apo form.
Analyse Crystal structure of EIF2ALPHA protein kinase GCN2: R794G hyperactivating… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZY4
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase GCN2
- EC
- 2.7.1.37
- UniProt
- P15442
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 271 | 41% helix, 19% strand | P15442 |
| B | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 249 | 39% helix, 20% strand | P15442 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.65 | 0.82 | 24 | empty |
| 2 | 436 | 0.63 | 0.77 | 49 | GOL |
| 3 | 203 | 0.51 | 0.77 | 30 | GOL |
| 4 | 112 | 0.39 | 0.75 | 17 | empty |
| 5 | 61 | 0.37 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1321 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 1ZY4 · Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo… · the same entry in another collection · chain A against A, TM-score 1.00
- P15442 · AlphaFold monomer V2.0 prediction for eif-2-alpha kinase GCN2 (P15442) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15442
- Elsewhere: RCSB PDB 1ZY4 · PDBe 1ZY4 · UniProt P15442
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.