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Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.

Analyse Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CEQ
Type: protein
Length: 304 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (L-lactate dehydrogenase)
EC: 1.1.1.27
UniProt: Q27743
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (L-lactate dehydrogenase) (EC 1.1.1.27)	protein	304	51% helix, 21% strand	Q27743

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	465	0.66	0.78	57	empty
2	125	0.43	0.76	21	empty
3	76	0.29	0.72	16	empty

Compared structures

1CEQ · Chloroquine binds in the cofactor binding site of plasmodium falciparum lactate… · the same entry in another collection · chain A against A, TM-score 1.00
Q27743 · AlphaFold monomer V2.0 prediction for L-lactate dehydrogenase (Q27743) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q27743
Elsewhere: RCSB PDB 1CEQ · PDBe 1CEQ · UniProt Q27743

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