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Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)

Analyse Crystal structure of bovine arrestin-2 in complex with inositol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZSH
Type: protein
Length: 354 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-arrestin 1
UniProt: P17870
Ligands: IHP, MG
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-arrestin 1	protein	354	3% helix, 47% strand	P17870

Ligands and binding sites

IHP · Inositol hexakisphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.67	0.91	32	empty
2	192	0.61	0.82	28	empty
3	64	0.31	0.75	15	empty
4	61	0.26	0.73	14	empty

Compared structures

1ZSH · Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6) · the same entry in another collection · chain A against A, TM-score 1.00
P17870 · AlphaFold monomer V2.0 prediction for beta-arrestin-1 (P17870) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17870
Elsewhere: RCSB PDB 1ZSH · PDBe 1ZSH · UniProt P17870

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