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Insulin, monoclinic crystal form
Analyse Insulin, monoclinic crystal form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZNJ
- Type
- protein
- Length
- 302 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01308
- Ligands
- IPH, ZN, CL
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, I, K | Insulin | protein | 21 | 57% helix, 5% strand | P01308 |
| B, J, L | Insulin | protein | 30 | 70% helix, 10% strand | P01308 |
| D, F | Insulin | protein | 29 | 72% helix, 10% strand | P01308 |
| H | Insulin | protein | 28 | 75% helix, 11% strand | P01308 |
Ligands and binding sites
- IPH · Phenol · ligand · 7 copies · chains A, B, F, J, C, D, L, E, G, H, I, K
- ZN · Zinc ion · metal · 2 copies · chains B, F, J, D, H, L
- CL · Chloride ion · ion · 2 copies · chains B, F, J, D, H, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.82 | 0.88 | 80 | IPH |
| 2 | 83 | 0.71 | 0.94 | 18 | IPH |
| 3 | 215 | 0.64 | 0.83 | 34 | IPH |
| 4 | 195 | 0.62 | 0.82 | 31 | IPH |
| 5 | 90 | 0.43 | 0.79 | 22 | CL, IPH |
Interfaces
39 interfaces between chains.
- F–H · 744 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 682 Ų buried · 15 hydrogen bonds · protein-protein
- J–L · 674 Ų buried · 10 hydrogen bonds · protein-protein
- I–J · 652 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 647 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 1ZNJ · Insulin, monoclinic crystal form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 1ZNJ · PDBe 1ZNJ · UniProt P01308
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