Research workbench
Human adenine phosphoribosyltransferase in apo and AMP complexed forms
Analyse Human adenine phosphoribosyltransferase in apo and AMP complexed forms in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZN9
- Type
- protein
- Length
- 358 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenine phosphoribosyltransferase
- EC
- 2.4.2.7
- UniProt
- P07741
- Ligands
- AMP
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Adenine phosphoribosyltransferase (EC 2.4.2.7) | protein | 179 | 35% helix, 35% strand | P07741 |
Ligands and binding sites
- AMP · Adenosine monophosphate · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 418 | 0.67 | 0.79 | 32 | empty |
| 2 | 350 | 0.60 | 0.77 | 30 | AMP |
Interfaces
1 interface between chains.
- A–B · 1570 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1ZN9 · Human Adenine Phosphoribosyltransferase in Apo and AMP Complexed Forms · the same entry in another collection · chain A against A, TM-score 1.00
- P07741 · AlphaFold monomer V2.0 prediction for adenine phosphoribosyltransferase (P07741) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07741
- Elsewhere: RCSB PDB 1ZN9 · PDBe 1ZN9 · UniProt P07741
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