Research workbench
Structure of human muscle pyruvate kinase (PKM2)
Analyse Structure of human muscle pyruvate kinase (PKM2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZJH
- Type
- protein
- Length
- 507 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pyruvate kinase, isozymes M1/M2
- EC
- 2.7.1.40
- UniProt
- P14618
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyruvate kinase, isozymes M1/M2 (EC 2.7.1.40) | protein | 507 | 37% helix, 19% strand | P14618 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.66 | 0.79 | 43 | empty |
| 2 | 177 | 0.57 | 0.81 | 31 | empty |
| 3 | 179 | 0.44 | 0.73 | 30 | empty |
| 4 | 74 | 0.36 | 0.77 | 19 | empty |
| 5 | 70 | 0.31 | 0.74 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14618
- Elsewhere: RCSB PDB 1ZJH · PDBe 1ZJH · UniProt P14618
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