Research workbench
Crystal structure of the catalytic domain of coagulation factor XI in complex with kunitz protease inhibitor domain of protease nexin II
Analyse Crystal structure of the catalytic domain of coagulation factor XI in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZJD
- Type
- protein
- Length
- 294 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catalytic domain of coagulation factor XI; Kunitz protease inhibitory domain of protease…
- EC
- 3.4.21.27
- UniProt
- P03951, P05067
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Catalytic domain of coagulation factor XI (EC 3.4.21.27) | protein | 237 | 12% helix, 34% strand | P03951 |
| B | Kunitz protease inhibitory domain of protease nexin II | protein | 57 | 14% helix, 28% strand | P05067 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.44 | 0.80 | 18 | empty |
| 2 | 94 | 0.36 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 829 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1ZJD · Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz… · the same entry in another collection · chain A against A, TM-score 1.00
- P03951 · AlphaFold monomer V2.0 prediction for coagulation factor XI (P03951) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03951
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 1ZJD · PDBe 1ZJD · UniProt P03951 · UniProt P05067
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.