Research workbench
Structure of yeast oxysterol binding protein OSH4 in complex with cholesterol
Analyse Structure of yeast oxysterol binding protein OSH4 in complex with cholesterol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZHY
- Type
- protein
- Length
- 436 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KES1 protein
- UniProt
- P35844
- Ligands
- CLR, PB
- Pockets
- 10 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | KES1 protein | protein | 436 | 31% helix, 28% strand | P35844 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 539 | 0.86 | 0.91 | 64 | CLR |
| 2 | 109 | 0.48 | 0.80 | 16 | empty |
| 3 | 171 | 0.47 | 0.76 | 26 | empty |
| 4 | 100 | 0.47 | 0.80 | 27 | empty |
| 5 | 115 | 0.41 | 0.76 | 25 | empty |
Compared structures
- 1ZHY · Structure of yeast oxysterol binding protein Osh4 in complex with cholesterol · the same entry in another collection · chain A against A, TM-score 1.00
- P35844 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein homolog 4 (P35844) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35844
- Elsewhere: RCSB PDB 1ZHY · PDBe 1ZHY · UniProt P35844
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