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Fructose-1,6-bisphosphate aldolase from rabbit muscle

Analyse Fructose-1,6-bisphosphate aldolase from rabbit muscle in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZAH
Type: protein
Length: 1,452 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fructose-bisphosphate aldolase a
EC: 4.1.2.13
UniProt: P00883
Pockets: 18 · best druggability 0.89

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Fructose-bisphosphate aldolase a (EC 4.1.2.13)	protein	363	44% helix, 14% strand	P00883

Pockets

18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1047	0.89	0.90	114	empty
2	518	0.84	0.90	70	empty
3	657	0.80	0.85	87	empty
4	793	0.79	0.83	103	empty
5	152	0.64	0.86	47	empty

Interfaces

6 interfaces between chains.

B–C · 1710 Å² buried · 28 hydrogen bonds · protein-protein
A–D · 1573 Å² buried · 26 hydrogen bonds · protein-protein
A–B · 1237 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 1214 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 107 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1ZAH · Fructose-1,6-bisphosphate aldolase from rabbit muscle · the same entry in another collection · chain D against D, TM-score 1.00
P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain D against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00883
Elsewhere: RCSB PDB 1ZAH · PDBe 1ZAH · UniProt P00883

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