Research workbench
Structure of the angiopoietin-2 recptor binding domain and identification of surfaces involved in TIE2 recognition
Analyse Structure of the angiopoietin-2 recptor binding domain and identification of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z3U
- Type
- protein
- Length
- 864 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiopoietin-2
- UniProt
- O15123
- Ligands
- CA
- Pockets
- 4 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Angiopoietin-2 | protein | 216 | 15% helix, 31% strand | O15123 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.35 | 0.75 | 19 | empty |
| 2 | 86 | 0.35 | 0.75 | 19 | empty |
| 3 | 78 | 0.34 | 0.75 | 19 | empty |
| 4 | 61 | 0.31 | 0.75 | 17 | empty |
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 1Z3U · Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces… · the same entry in another collection · chain D against D, TM-score 1.00
- O15123 · AlphaFold monomer V2.0 prediction for angiopoietin-2 (O15123) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15123
- Elsewhere: RCSB PDB 1Z3U · PDBe 1Z3U · UniProt O15123
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