Research workbench
Structural model for the interaction between RPA32 C-terminal domain and SV40 T antigen origin binding domain.
Analyse Structural model for the interaction between RPA32 C-terminal domain and SV40 T… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z1D
- Type
- protein
- Length
- 200 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication protein a 32 kda subunit; Large T antigen
- UniProt
- P15927, P03070
- Pockets
- 2 · best druggability 0.58
Structure
solution nmr · 2 distinct chains · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replication protein a 32 kda subunit | protein | 69 | 45% helix, 13% strand | P15927 |
| B | Large T antigen | protein | 131 | 27% helix, 29% strand | P03070 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.58 | 0.83 | 29 | empty |
| 2 | 50 | 0.26 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 646 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1Z1D · Structural Model for the interaction between RPA32 C-terminal domain and SV40 T antigen… · the same entry in another collection · chain A against A, TM-score 1.00
- P15927 · AlphaFold monomer V2.0 prediction for replication protein a 32 kda subunit (P15927) · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15927
- Every structure of UniProt P03070
- Elsewhere: RCSB PDB 1Z1D · PDBe 1Z1D · UniProt P15927 · UniProt P03070
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