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Structure of GTP-bound RAB22Q64L GTPase in complex with the minimal rab binding domain of rabenosyn-5
Analyse Structure of GTP-bound RAB22Q64L GTPase in complex with the minimal rab binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z0J
- Type
- protein
- Length
- 220 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-22A; Fyve-finger-containing RAB5 effector protein rabenosyn-5
- UniProt
- P35285
- Ligands
- GTP, MG
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-22A | protein | 169 | 36% helix, 29% strand | P35285 |
| B | Fyve-finger-containing RAB5 effector protein rabenosyn-5 | protein | 51 | 80% helix, 0% strand | — |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.49 | 0.80 | 26 | MG, GTP |
Interfaces
1 interface between chains.
- A–B · 709 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1Z0J · Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P35285 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-22A (P35285) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35285
- Elsewhere: RCSB PDB 1Z0J · PDBe 1Z0J · UniProt P35285
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