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Crystal structure of human translationally controlled tumour associated protein
Analyse Crystal structure of human translationally controlled tumour associated protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YZ1
- Type
- protein
- Length
- 580 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translationally controlled tumor protein
- UniProt
- P13693
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translationally controlled tumor protein | protein | 146 | 38% helix, 31% strand | P13693 |
| B | Translationally controlled tumor protein | protein | 145 | 37% helix, 32% strand | P13693 |
| C | Translationally controlled tumor protein | protein | 145 | 37% helix, 32% strand | P13693 |
| D | Translationally controlled tumor protein | protein | 144 | 39% helix, 31% strand | P13693 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 225 | 0.66 | 0.84 | 31 | empty |
| 2 | 149 | 0.62 | 0.85 | 27 | empty |
| 3 | 308 | 0.54 | 0.75 | 35 | empty |
| 4 | 112 | 0.36 | 0.73 | 20 | empty |
| 5 | 60 | 0.30 | 0.74 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–D · 372 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 370 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 242 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 131 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1YZ1 · Crystal structure of human translationally controlled tumour associated protein · the same entry in another collection · chain D against D, TM-score 1.00
- P13693 · AlphaFold monomer V2.0 prediction for translationally-controlled tumor protein (P13693) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13693
- Elsewhere: RCSB PDB 1YZ1 · PDBe 1YZ1 · UniProt P13693
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