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Structure and inter-domain interactions of domain II from the blood stage malarial protein, apical membrane antigen 1
Analyse Structure and inter-domain interactions of domain II from the blood stage… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YXE
- Type
- protein
- Length
- 140 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apical membrane antigen 1
- UniProt
- P22621
- Pockets
- 2 · best druggability 0.62
Structure
solution nmr · 1 distinct chain · 17% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apical membrane antigen 1 | protein | 140 | 17% helix, 9% strand | P22621 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 447 | 0.62 | 0.76 | 45 | empty |
| 2 | 257 | 0.57 | 0.78 | 36 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1YXE · Structure and inter-domain interactions of domain II from the blood stage malarial… · the same entry in another collection · chain A against A, TM-score 1.00
- P22621 · AlphaFold monomer V2.0 prediction for apical membrane antigen 1 (P22621) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22621
- Elsewhere: RCSB PDB 1YXE · PDBe 1YXE · UniProt P22621
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