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Crystal structure of the response regulatory protein prra from mycobacterium tuberculosis

Analyse Crystal structure of the response regulatory protein prra from mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YS6
Type: protein
Length: 452 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulatory protein prra
UniProt: Q10531
Ligands: CA
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulatory protein prra	protein	225	40% helix, 22% strand	Q10531
B	Transcriptional regulatory protein prra	protein	227	40% helix, 21% strand	Q10531

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A, B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1125	0.74	0.77	84	CA

Interfaces

1 interface between chains.

A–B · 507 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1YS6 · Crystal structure of the response regulatory protein PrrA from Mycobacterium Tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q10531
Elsewhere: RCSB PDB 1YS6 · PDBe 1YS6 · UniProt Q10531

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