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The crystal structure of a partial mouse notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold

Analyse The crystal structure of a partial mouse notch-1 ankyrin domain: repeats 4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YMP
Type: protein
Length: 262 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Notch 1 protein
UniProt: Q07008
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Notch 1 protein	protein	131	50% helix, 0% strand	Q07008

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	116	0.69	0.91	31	empty
2	62	0.46	0.83	18	empty
3	59	0.30	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 633 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1YMP · The Crystal Structure of a Partial Mouse Notch-1 Ankyrin Domain: Repeats 4 Through 7… · the same entry in another collection · chain A against A, TM-score 1.00
Q07008 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (Q07008) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07008
Elsewhere: RCSB PDB 1YMP · PDBe 1YMP · UniProt Q07008

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