Research workbench
G protein-coupled receptor kinase 2 (GRK2)
Analyse G protein-coupled receptor kinase 2 (GRK2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YM7
- Type
- protein
- Length
- 2,422 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-adrenergic receptor kinase 1
- EC
- 2.7.1.126
- UniProt
- P21146
- Pockets
- 20 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Beta-adrenergic receptor kinase 1 (EC 2.7.1.126) | protein | 608 | 44% helix, 14% strand | P21146 |
| C | Beta-adrenergic receptor kinase 1 (EC 2.7.1.126) | protein | 607 | 44% helix, 16% strand | P21146 |
| D | Beta-adrenergic receptor kinase 1 (EC 2.7.1.126) | protein | 599 | 44% helix, 16% strand | P21146 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 397 | 0.62 | 0.77 | 46 | empty |
| 2 | 173 | 0.58 | 0.82 | 33 | empty |
| 3 | 181 | 0.58 | 0.81 | 31 | empty |
| 4 | 408 | 0.58 | 0.75 | 41 | empty |
| 5 | 195 | 0.57 | 0.80 | 31 | empty |
Interfaces
3 interfaces between chains.
- B–D · 915 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 898 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 817 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21146
- Elsewhere: RCSB PDB 1YM7 · PDBe 1YM7 · UniProt P21146
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