Research workbench
Crystal structure analysis of the oxidized form of the M314I mutant of peptidylglycine alpha-hydroxylating monooxygenase
Analyse Crystal structure analysis of the oxidized form of the M314I mutant of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YI9
- Type
- protein
- Length
- 295 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-glycine alpha-amidating monooxygenase
- EC
- 1.14.17.3
- UniProt
- P14925
- Ligands
- CU
- Pockets
- 4 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-glycine alpha-amidating monooxygenase (EC 1.14.17.3) | protein | 295 | 5% helix, 51% strand | P14925 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.46 | 0.85 | 19 | empty |
| 2 | 162 | 0.45 | 0.75 | 29 | empty |
| 3 | 64 | 0.37 | 0.78 | 15 | empty |
| 4 | 51 | 0.27 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1YI9 · Crystal Structure Analysis of the oxidized form of the M314I mutant of Peptidylglycine… · the same entry in another collection · chain A against A, TM-score 1.00
- P14925 · AlphaFold monomer V2.0 prediction for peptidylglycine alpha-amidating monooxygenase… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14925
- Elsewhere: RCSB PDB 1YI9 · PDBe 1YI9 · UniProt P14925
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