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Structure of the brct repeats of BRCA1 bound to a ctip phosphopeptide.

Analyse Structure of the brct repeats of BRCA1 bound to a ctip phosphopeptide. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1Y98
Type
protein
Length
223 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Breast cancer type 1 susceptibility protein; Ctip phosphorylated peptide
UniProt
P38398
Ligands
CO, SO4

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 18% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ABreast cancer type 1 susceptibility proteinprotein21135% helix, 19% strandP38398
BCtip phosphorylated peptideprotein120% helix, 8% strand—

Ligands and binding sites

  • CO · Cobalt (II) ion · metal · chains A
  • SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

  • A–B · 545 Ų buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

  • 1Y98 · Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. · the same entry in another collection · chain A against A, TM-score 1.00
  • P38398 · AlphaFold monomer V2.0 prediction for breast cancer type 1 susceptibility protein (P38398) · a predicted model of the same protein · chain A against A, TM-score 0.99

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