Sulfolobus solfataricus uracil phosphoribosyltransferase in complex with uridine 5'-monophosphate (ump) and cytidine 5'-triphosphate (CTP)

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 30% strand (DSSP).

Ligands and binding sites

• U5P · Uridine-5'-monophosphate · ligand · 8 copies · chains A, B, C, D, E, F, G, H
• CTP · Cytidine-5'-triphosphate · ligand · 8 copies · chains A, E, H, C, F, G, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Interfaces

13 interfaces between chains.

• C–G · 1863 Ų buried · 25 hydrogen bonds · protein-protein
• A–E · 1836 Ų buried · 23 hydrogen bonds · protein-protein
• D–H · 1824 Ų buried · 22 hydrogen bonds · protein-protein
• B–F · 1818 Ų buried · 21 hydrogen bonds · protein-protein
• B–G · 1082 Ų buried · 19 hydrogen bonds · protein-protein

Compared structures

• 1XTU · Sulfolobus solfataricus uracil phosphoribosyltransferase in complex with uridine… · the same entry in another collection · chain H against H, TM-score 1.00
• Q980Q4 · AlphaFold monomer V2.0 prediction for uracil phosphoribosyltransferase (Q980Q4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q980Q4
• Elsewhere: RCSB PDB 1XTU · PDBe 1XTU · UniProt Q980Q4