Research workbench
Crystal structure of guinea pig 11BETA-hydroxysteroid dehydrogenase type 1
Analyse Crystal structure of guinea pig 11BETA-hydroxysteroid dehydrogenase type 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XSE
- Type
- protein
- Length
- 548 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 11BETA-hydroxysteroid dehydrogenase type 1
- EC
- 1.1.1.146
- UniProt
- Q6QLL4
- Ligands
- NDP
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 11BETA-hydroxysteroid dehydrogenase type 1 (EC 1.1.1.146) | protein | 274 | 53% helix, 15% strand | Q6QLL4 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.82 | 0.86 | 70 | NDP |
| 2 | 583 | 0.81 | 0.87 | 65 | NDP |
| 3 | 112 | 0.43 | 0.77 | 23 | empty |
| 4 | 98 | 0.43 | 0.78 | 20 | empty |
| 5 | 104 | 0.42 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 3021 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 1XSE · Crystal Structure of Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q6QLL4 · AlphaFold monomer V2.0 prediction for corticosteroid 11-beta- dehydrogenase isozyme 1… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6QLL4
- Elsewhere: RCSB PDB 1XSE · PDBe 1XSE · UniProt Q6QLL4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.