Research workbench
Structural basis of snt ptb domain interactions with distinct neurotrophic receptors
Analyse Structural basis of snt ptb domain interactions with distinct neurotrophic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XR0
- Type
- protein
- Length
- 151 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Basic fibroblast growth factor receptor 1; Fgfr signalling adaptor snt-1
- UniProt
- P11362, Q8WU20
- Pockets
- 1 · best druggability 0.38
Structure
solution nmr · 2 distinct chains · 9% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Basic fibroblast growth factor receptor 1 | protein | 22 | 0% helix, 9% strand | P11362 |
| B | Fgfr signalling adaptor snt-1 | protein | 129 | 11% helix, 33% strand | Q8WU20 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.38 | 0.80 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1432 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 1XR0 · Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WU20 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor substrate 2… · a predicted model of the same protein · chain B against A, TM-score 0.72
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain A against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Every structure of UniProt Q8WU20
- Elsewhere: RCSB PDB 1XR0 · PDBe 1XR0 · UniProt P11362 · UniProt Q8WU20
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