Research workbench
Crystal structure of PKC-theta complexed with staurosporine at 2A resolution
Analyse Crystal structure of PKC-theta complexed with staurosporine at 2A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XJD
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C, theta type
- EC
- 2.7.1.-
- UniProt
- Q04759
- Ligands
- STU
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C, theta type (EC 2.7.1.-) | protein | 282 | 38% helix, 18% strand | Q04759 |
Ligands and binding sites
- STU · Staurosporine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 235 | 0.67 | 0.84 | 25 | STU |
| 2 | 67 | 0.31 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 1XJD · Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q04759 · AlphaFold monomer V2.0 prediction for protein kinase C theta type (Q04759) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04759
- Elsewhere: RCSB PDB 1XJD · PDBe 1XJD · UniProt Q04759
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