Research workbench
Clathrin D6 coat with auxilin J-domain
Analyse Clathrin D6 coat with auxilin J-domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XI5
- Type
- protein
- Length
- 15,696 residues
- Chains
- 18
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Clathrin heavy chain; Auxilin J-domain
- UniProt
- P49951, Q27974
- Pockets
- 20 · best druggability 0.58
Structure
electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I | Clathrin heavy chain | protein | 1630 | 0% helix, 0% strand | P49951 |
| J, K, L, M, N, O, P, Q, R | Auxilin J-domain | protein | 114 | 0% helix, 0% strand | Q27974 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.58 | 0.74 | 64 | empty |
| 2 | 299 | 0.56 | 0.74 | 51 | empty |
| 3 | 268 | 0.55 | 0.74 | 44 | empty |
| 4 | 271 | 0.53 | 0.73 | 57 | empty |
| 5 | 262 | 0.53 | 0.73 | 53 | empty |
Interfaces
20 interfaces between chains.
- C–D · 792 Ų buried · 0 hydrogen bonds · protein-protein
- F–G · 649 Ų buried · 0 hydrogen bonds · protein-protein
- A–F · 530 Ų buried · 0 hydrogen bonds · protein-protein
- G–I · 238 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 213 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1XI5 · Clathrin D6 coat with auxilin J-domain · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49951
- Every structure of UniProt Q27974
- Elsewhere: RCSB PDB 1XI5 · PDBe 1XI5 · UniProt P49951 · UniProt Q27974
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