Research workbench
Structure of glutamate transporter homolog from pyrococcus horikoshii
Analyse Structure of glutamate transporter homolog from pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XFH
- Type
- protein
- Length
- 1,215 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton glutamate symport protein
- UniProt
- O59010
- Pockets
- 14 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Proton glutamate symport protein | protein | 405 | 71% helix, 0% strand | O59010 |
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 581 | 0.88 | 0.92 | 42 | empty |
| 2 | 385 | 0.56 | 0.73 | 59 | empty |
| 3 | 277 | 0.51 | 0.73 | 36 | empty |
| 4 | 214 | 0.47 | 0.74 | 34 | empty |
| 5 | 176 | 0.44 | 0.73 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1074 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 1051 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 1049 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1XFH · Structure of glutamate transporter homolog from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
- O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 1XFH · PDBe 1XFH · UniProt O59010
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