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Crystal structure of the dh-pH-cat module of son of sevenless (sos)

Analyse Crystal structure of the dh-pH-cat module of son of sevenless (sos) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XD4
Type: protein
Length: 1,648 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Son of sevenless protein homolog 1
UniProt: Q07889
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Son of sevenless protein homolog 1	protein	824	58% helix, 7% strand	Q07889

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1195	0.81	0.82	99	empty
2	803	0.73	0.78	83	empty
3	544	0.71	0.80	73	empty
4	241	0.66	0.84	36	empty
5	435	0.61	0.75	41	empty

Interfaces

1 interface between chains.

A–B · 1715 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1XD4 · Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) · the same entry in another collection · chain A against A, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 1XD4 · PDBe 1XD4 · UniProt Q07889

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