Research workbench
Crystal structure of the semet-derivative copper homeostasis protein (cutcm) with calcium binding from shigella flexneri 2A str. 301
Analyse Crystal structure of the semet-derivative copper homeostasis protein (cutcm)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1X8C
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper homeostasis protein cutc
- UniProt
- P67825
- Ligands
- CA
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Copper homeostasis protein cutc | protein | 234 | 41% helix, 21% strand | P67825 |
| B | Copper homeostasis protein cutc | protein | 238 | 41% helix, 20% strand | P67825 |
Ligands and binding sites
- CA · Calcium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.70 | 0.89 | 60 | empty |
| 2 | 260 | 0.56 | 0.77 | 37 | empty |
| 3 | 241 | 0.55 | 0.78 | 31 | empty |
| 4 | 118 | 0.52 | 0.81 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1902 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified (engineered).
Compared structures
- 1X8C · Crystal structure of the SeMet-derivative copper homeostasis protein (cutCm) with calcium… · the same entry in another collection · chain A against A, TM-score 1.00
- P67825 · AlphaFold monomer V2.0 prediction for copper homeostasis protein cutc (P67825) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67825
- Elsewhere: RCSB PDB 1X8C · PDBe 1X8C · UniProt P67825
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