Research workbench
X11 ptb domain
Analyse X11 ptb domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1X11
- Type
- protein
- Length
- 282 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- X11; 13-mer peptide
- UniProt
- Q02410, P05067
- Pockets
- 3 · best druggability 0.35
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | X11 | protein | 135 | 30% helix, 40% strand | Q02410 |
| C | 13-mer peptide | protein | 12 | 25% helix, 33% strand | P05067 |
| B | X11 | protein | 122 | 36% helix, 42% strand | Q02410 |
| D | 13-mer peptide | protein | 13 | 31% helix, 31% strand | P05067 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.35 | 0.73 | 16 | empty |
| 2 | 64 | 0.32 | 0.76 | 11 | empty |
| 3 | 50 | 0.31 | 0.77 | 13 | empty |
Interfaces
4 interfaces between chains.
- A–C · 977 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 811 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 612 Ų buried · 6 hydrogen bonds · protein-protein
- C–B · 94 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 17 modified (engineered).
Compared structures
- 1X11 · X11 ptb domain · the same entry in another collection · chain D against D, TM-score 1.00
- Q02410 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 precursor protein-binding family a… · a predicted model of the same protein · chain B against A, TM-score 0.92
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain C against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02410
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 1X11 · PDBe 1X11 · UniProt Q02410 · UniProt P05067
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