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Structure of apo, unphosphorylated, P38 mitogen activated protein kinase P38 (P38 MAP kinase) the mammalian homologue of the yeast HOG1 protein
Analyse Structure of apo, unphosphorylated, P38 mitogen activated protein kinase P38… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1WFC
- Type
- protein
- Length
- 340 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase P38
- EC
- 2.7.1.-
- UniProt
- Q16539
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase P38 (EC 2.7.1.-) | protein | 340 | 43% helix, 15% strand | Q16539 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 555 | 0.68 | 0.78 | 51 | empty |
| 2 | 100 | 0.40 | 0.76 | 16 | empty |
| 3 | 66 | 0.32 | 0.76 | 16 | empty |
| 4 | 65 | 0.29 | 0.73 | 17 | empty |
| 5 | 52 | 0.28 | 0.74 | 13 | empty |
Compared structures
- 1WFC · Structure of apo, unphosphorylated, P38 mitogen activated protein kinase P38 (P38 MAP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16539
- Elsewhere: RCSB PDB 1WFC · PDBe 1WFC · UniProt Q16539
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