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A novel conotoxin from conus textile with unusual post-translational modifications reduces presynaptic calcium influx, NMR, 1 structure, glycosylated protein

Analyse A novel conotoxin from conus textile with unusual post-translational… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WCT
Type: protein
Length: 13 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Omegac-txix
UniProt: P81755
Ligands: NGA, GAL

Structure

solution nmr · 1 distinct chain · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Omegac-txix	protein	13	0% helix, 0% strand	P81755

Ligands and binding sites

NGA · 2-acetamido-2-deoxy-beta-D-galactopyranose · sugar · chains A
GAL · beta-D-galactopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 4 modified, 2 disulfide, 1 glycan (disulfide, carboxylation, O-glycosylation, hydroxylation, nonstandard).

Compared structures

1WCT · A novel conotoxin from conus textile with unusual post-translational modifications… · the same entry in another collection · chain A against A, TM-score 1.00
P81755 · AlphaFold monomer V2.0 prediction for epsilon-conotoxin txva (P81755) · a predicted model of the same protein · chain A against A, TM-score 0.40

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P81755
Elsewhere: RCSB PDB 1WCT · PDBe 1WCT · UniProt P81755

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