Research workbench
Crystal structure of form B monoclinic crystal of insulin
Analyse Crystal structure of form B monoclinic crystal of insulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1WAV
- Type
- protein
- Length
- 306 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01315
- Ligands
- IPH, ZN
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, I, K | Insulin | protein | 21 | 48% helix, 0% strand | P01315 |
| B, D, F, H, J, L | Insulin | protein | 30 | 70% helix, 10% strand | P01315 |
Ligands and binding sites
- IPH · Phenol · ligand · 6 copies · chains A, B, F, C, D, L, E, J, G, H, K, I
- ZN · Zinc ion · metal · 2 copies · chains B, F, J, D, H, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.82 | 0.90 | 63 | IPH |
| 2 | 201 | 0.66 | 0.84 | 30 | IPH |
| 3 | 182 | 0.65 | 0.85 | 32 | IPH |
| 4 | 132 | 0.61 | 0.85 | 26 | IPH |
| 5 | 142 | 0.61 | 0.84 | 30 | IPH |
Interfaces
37 interfaces between chains.
- F–H · 702 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 679 Ų buried · 6 hydrogen bonds · protein-protein
- J–L · 676 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 653 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 646 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 1WAV · Crystal structure of form B monoclinic crystal of insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01315
- Elsewhere: RCSB PDB 1WAV · PDBe 1WAV · UniProt P01315
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.