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Proteolytic fragment of CRM1 spanning six C-terminal heat repeats

Analyse Proteolytic fragment of CRM1 spanning six C-terminal heat repeats in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1W9C
Type: protein
Length: 642 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRM1 protein
UniProt: O14980
Pockets: 3 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CRM1 protein	protein	321	78% helix, 0% strand	O14980

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.38	0.78	15	empty
2	64	0.38	0.79	18	empty
3	61	0.35	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 989 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1W9C · Proteolytic fragment of CRM1 spanning six C-terminal HEAT repeats · the same entry in another collection · chain A against A, TM-score 1.00
O14980 · AlphaFold monomer V2.0 prediction for exportin-1 (O14980) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14980
Elsewhere: RCSB PDB 1W9C · PDBe 1W9C · UniProt O14980

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